Viral Determinants of HIV-1 Macrophage Tropism
نویسندگان
چکیده
منابع مشابه
Viral Determinants of HIV-1 Macrophage Tropism
Macrophages are important target cells for HIV-1 infection that play significant roles in the maintenance of viral reservoirs and other aspects of pathogenesis. Understanding the determinants of HIV-1 tropism for macrophages will inform HIV-1 control and eradication strategies. Tropism for macrophages is both qualitative (infection or not) and quantitative (replication capacity). For example ma...
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Human immunodeficiency virus type 1 (HIV-1) is tropic and pathogenic only for humans, and does not replicate in macaque monkeys routinely used for experimental infections. This specially narrow host range (species tropism) has impeded much the progress of HIV-1/acquired immunodeficiency syndrome (AIDS) basic research. Extensive studies on the underlying mechanism have revealed that Vif, one of ...
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The genome of the human immunodeficiency virus type 1 (HIV-1) is highly heterogeneous. Some of this genomic variability is reflected in the biologic and serologic differences observed among various strains of HIV-1. To map the viral determinants that correlate with pathogenicity of the virus, recombinant viruses were generated between biologically active molecular clones of HIV-1 strains that s...
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متن کاملViral Tropism
The authors in this Research Topic have highlighted the importance of viral tropism by presenting biological phenomena and their underpinning host cellular and molecular bases. The biologically unique phenomenon of viral tropism is not only of interest to virologists to bring progress to their basic science but also highly relevant to clinical studies with the goal to design new anti-viral stra...
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ژورنال
عنوان ژورنال: Viruses
سال: 2011
ISSN: 1999-4915
DOI: 10.3390/v3112255